Trivia: A little nod to another Blue Sky Studios Production, "Ice Age". When Rodney is looking around Robot city, he comes across a red robot that plays hip-hop. As Rodney walks away nervously ("Uh, n-n-never mind"), pause the frame just before the shot changes and you'll see (on the left) a yellow, mechanical Sid. Sid is the sloth (and the main character) from "Ice Age". (00:15:25)
Trivia: A popular film poster shows Emily and Victor reaching their hands toward one another. Emily's bony hand is on her right and Victor's suit and vest are backwards (note its buttons). Some say it was for legal reasons - Johnny Depp's name was supposed to appear on the poster first because of a contract, and they wanted the characters underneath the corresponding star names, hence the issue. Others say it was simply because the picture looked better with the bride on the right side.
Trivia: At the very end of the film, when the group uses the Improbability Drive to go to the Restaurant at the End of the Universe, there are a lot of images that flash onto the screen when the drive is activated, so in the other parts of the film. In this case, the very last image shown is the face of Douglas Adams, the creator of the Hitchhiker series.
Trivia: Fantastic Four creator (and Marvel editor-in-chief) Stan Lee has a cameo as Willy Lumpkin, the Four's mailman. It was his only Marvel movie cameo based on an actual comic character.
Trivia: In the room with the razor blade box, if you look at the top of the frame, you can see a lock with a key in it. If the actress walked a few feet further, she could've unlocked the box and gotten the syringe. Obviously this would've defeated the purpose of her dying, but interesting to point out. Confirmed in DVD special features. (01:06:00)
Trivia: Gene Barry and Ann Robinson, stars of the 1953 version of this movie, make a small cameo in this movie as Mary Ann's parents. They are at the end when the whole family is reunited.