Continuity mistake: Madame Blueberry's hair changes from brown to blonde throughout the film.
Suggested correction: Her hairstyle and hat change. She bought a wig and a new hat while at StuffMart, and continues wearing them until the final scene, where she is back to being herself.
Continuity mistake: When the girl in the orange slides over the stones and then falls to the ground tumbling over and over, you can see that her arms are completely protected by black arm protectors, yet when she comes to a complete stop, they are now missing.
Continuity mistake: Near the end, Jake hides in a dog crate. The dog runs out of the plane, and the baggage guys chase after it. While this is happening, a bag is coming down the conveyor belt. Between the first shot and the next angle, the bag jumps backwards.
Continuity mistake: When the geckos notice Thang, Rose, Didi and Sal attempting to sneak past them, the four are standing directly in front of the geckos. The geckos then begin to approach the four and there is suddenly a large distance in between them. (00:22:55)
Continuity mistake: When the two cats move past the yawning rat to go up the crane lifter, the door is shut, but they slip into its semi-opened door when they reach the platform in the next shot. (00:06:05)