Factual error: When the boys are sent back to the Cretaceous era, they come across a leptictidium, a small, bipedal mammal they call "Leppy." Leptictidium were not around in the cretaceous, they didn't appear until around ten million years after the dinosaurs went extinct, in the early Paleogene. They also lived in Europe, not North America.
The League of Villains - S3-E16
Factual error: As the villains are approaching to Earth, South America is shown just under Asia, connected to the Arabian Peninsula and the southern tip of India. The two continents are nowhere near enough to each other to be seen at the same time from space, much less connected. They are on opposite sides of the Pacific ocean, over 10,000 miles (16,000 km) apart. (00:06:45)
Factual error: Jimmy tells Carl and Sheen they were sent back 200 million years and throughout the episode, they say they are in the Cretaceous period. The Cretaceous period actually started around 145 million years ago. They would actually be in the mid Jurassic period. Also, the tyrannosaurs didn't appear until much later in the Cretaceous, around 70 million years ago.
Factual error: Jimmy consistently says he needs to extract the mitochondria from a virus to cure everyone. In actual biology virus' have no mitochondria or other complex molecules within them.