Revealing mistake: When Natalie shows Nick the murdered museum guard's bite wounds in the morgue, the "dead" man's carotid artery is pulsing quite healthily. (00:08:30)
Dance By The Light Of The Moon - S1-E7
Revealing mistake: The flashbacks to 1228 in this episode portray some of the same events - Janette seducing Nick, LaCroix making Nick a vampire - that are also shown in "Dark Knight." But here, Nick, Janette and LaCroix are all wearing completely different costumes.
Answer: Nick was sick and tired of being an immortal bloodsucker. He wanted to be human, fall in love, get married, have children, grow old and die. As for Janette, according to her, she fell in love and the passion she felt "cured" her of her blood lust.