Megan O'Hara - S1-E6
Continuity mistake: As Christian and Sean are consulting with Megan O'Hara and her husband, you can see a clear shot of the clipboard of her file, and her age states 31 years old. About a month later, Megan dies (Adelle Coffin episode) and after the funeral while Julia and Sean are in an argument concerning his affair with Megan, Julia expresses remorse that Megan died at 36 years old.
Sophia Lopez - S1-E4
Continuity mistake: During the scene where "Fluffer girl" is talking to Matt explaining she has the clap, in one camera angle Matt is seen next to her slowly stroking her back with his hand in a caring and concerned matter. Not even a split second later or two words further in her sentence, a different camera angle now shows Matt with his hands out in front of him on his lap.
Continuity mistake: Just as the episode starts, Dr. Troy is reattaching a thumb and some fingers to a patient. Liz then tells Dr. Troy that he incorrectly placed the middle (longer) finger where the index finger should be. As she says this, the camera shot of the hand from a few feet away shows that the fingers ARE correct, then the following close-up show shows the fingers attached wrong, not to mention if you look real close during this shot, the fingers flinch a little.
Continuity mistake: When Matt and Henry are driving after getting high, they accidentally hit Cara Fitzgerald with Henry's car. Matt then slams on the brakes, and you can see black skid marks. After the car stops and they get out to look around, several different camera angles show no skid marks at all behind the car now.
Continuity mistake: During the scene where Sean and Megan are talking on the bench after abruptly leaving the restaurant, pay attention to Sean's arm as it is around Megan. It changes positions several times around Megan's back and shoulders during different camera angles, and he never noticebly moved it.
Sophia Lopez - S1-E4
Continuity mistake: During the scene where Sean first meets Sophia Lopez in his office and he is about to counsel her, one camera view has Sean looking down at his notes and writing something, then looking up at Sophia as he begins speaking. A split second later, now from the opposite camera view, Sean looks up again and hasn't begun speaking yet.
Sophia Lopez - S1-E4
Continuity mistake: When Matt talks to the "fluffer", her lollipop disappears from her mouth in between shots. She then raises her arm and puts the lollipop back in her mouth. (00:20:35)
Sophia Lopez - S1-E4
Continuity mistake: When Christian talks to Matt outside the school, Matt hears the school bell ring and glances at the school and then back at Christian. In the next shot, he's facing the school and turns around to look at Christian again. (00:39:55)
Answer: It's a computer graphic.