Continuity mistake: At the beginning, if you watch the clock as Homer walks in, the time changes between shots. (00:01:30)
Continuity mistake: When the paper falls on Skinner there are blue and white tiles in the doorway, when he is hanging from the hoover, the floor is completely blue. (00:19:20)
Continuity mistake: The paper that Bart draws Skinner on changes from ruled to plain. (00:14:00)
Continuity mistake: When Bart draws Skinner before he is declared missing, the paper is flat on the desk in the first shot and held upright in the next. (00:14:05)
Continuity mistake: After Itchy and Scratchy we see Bart and the mob sat in the bar, the mobster at the end of the bar has his drink in 1 hand or 2 hands depending on the shot. (00:08:16)
Continuity mistake: Bart clears some dust off the picture of the Manhattan, once he's made the drink a few seconds later all the dust has gone. (00:06:40)
Continuity mistake: The drink above the Manhattan on the board changes name and picture. (00:06:40)
Continuity mistake: When Bart falls in the entranceway, a puddle appears under his head between shots. (00:05:30)
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer