Continuity mistake: During the 20 years ago flashback, when Maude goes to spray water on Homer's pants, she is sitting on a tree in the background. When Homer and Marge talk, she doesn't spray water on his pants, but in the next shot she is gone. (00:17:35)
Revealing mistake: When Alberto says "If you had completed your seduction of me, I never would have met Sylvia," his shirt collar briefly turns into the same color as his blazer.
Answer: I'm not sure if this is the one you're thinking of, but an episode of "Ray Bradbury Theatre," called "A Sound of Thunder," dealt with a similar matter: a group of hunters travel back in time to hunt dinosaurs, only to find things have changed when they get back because someone stepped on a butterfly.
Xofer