TedStixon

Answer: Originally, the women never deteriorated. You see that at the spring party, the women are completely fine, and in the original third act, they never started to peel. The last two scenes in the film are reshoots. After test screenings, they decided to end the film in a more wacky way, so the element of Mad and Hel deteriorating and not being able to take care of each other that well (and being outcasts) was implemented. A simple audio change of "It will be better for both of you to get IT back" from Lisle to "him back." Originally, the women went after Ernest (who found the potion bottle intact in the pool), who drives off to his neighbourhood bar (you can see it in the trailer). There, Ernest stages his death with the help of his friend Toni. Sadly for Ernest, the women do end up getting the potion back, so they ended up being on good terms with Lisle instead of being outcasts. Twenty-seven years later, the women are still completely the same, and Lisle has someone who can take care of their 'puckering.'

Answer: They were warned earlier in the film that they needed to take care of their bodies. But obviously, they put them through a lot of abuse. They didn't take care of themselves, needing to be patched up frequently and whatnot. As a result, at this point, their bodies are like living mannequins more than human bodies. They simply break apart with force, such as falling down the stairs.

TedStixon

Answer: Their bodies had become physically corrupted and fragile from the extreme anti-aging potion, and any stress caused catastrophic damage.

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