Other mistake: At one point on talk radio show Chatterbox, Maria (Salvatore's girlfriend) calls up to ask Lazlow for romantic advice. In her call, she describes the events that occur in the game involving Salvatore betraying the game's protagonist and how Maria is falling for him. This conversation can be heard on the radio before the events have actually happened in the storyline.
Continuity mistake: Claude obtains his default outfit after escaping from the police convoy. However, during the bank heist, prior to getting shot and arrested, Claude has these clothes already on.
Factual error: Liberty City is a fictional place but it is situated in the real USA. Despite that, the digital temperature clocks in Bedford Point Square display the temp in Celsius. The American temperature unit is Fahrenheit, not Celsius.
Bug: On the 1st island there is a long tunnel. In the middle of it are 4 bums (Hobos, tramps, whatever) in a circle with a package in the middle. If you get a Bobcat truck and drive between them without running any over or beeping your horn, you can progress with the glitch. Park there and stand on the roof. If you jump off the front of the truck, another Hobo will fall from the top of the tunnel. Keep doing this until you get loads of them and kill them as they all contain Molotovs.