Trivia: When you select the Gingerbread man for multiplayer he says "Bite my crunchy brown ass." A direct reference to Futurama's Bender and his catch phrase "Bite my shiny metal ass."
Trivia: In the eighth level (You Genius, U-Genix), after you get the disguise, Amy says "Remember, your name is Gordon now. Lead the way, doctor." This is a reference to Half-Life's main character Doctor Gordon Freeman.
Trivia: In the fourth level (The Khallos Express) after the Khallos uses the poison gas you can control his pet cat.
Trivia: A drunk character appears in every level of the game aside from the first and last.