Factual error: The dude handcuffed to the radiator has a single piece of duct tape across his mouth maybe 8 inches in length. The sweat and oils, and somebody just moving their mouth will break the tape free from their mouth. A person can scream all they want. To properly do it properly, a ball gag like the one used in Pulp Fiction needs to be used. A piece of tape does nothing, I've taped my own mouth to try it. (00:46:30 - 00:47:30)
Revealing mistake: Towards the end, Jake Gyllenhaal is browsing the internet on a computer running Windows 7...despite the "no network" notification icon at the bottom right of the taskbar. (01:25:05)
Other mistake: When Detective Loki is researching the article detailing Keller's father's death, the date on the computer is 2/27/2013. This takes place shortly after Thanksgiving, which would set the movie in late November or early December, not February. (01:25:05)
Continuity mistake: In the shot where Holly is done injecting Anna with the syringe and stands up to shoot at Detective Loki, the syringe and two "medicine/poison" bottles are all close together next to Anna's hair. Next three shots showing the room far out with Holly getting shot and killed has the two bottles next to the edge of the rug and very far from Anna's hair, as well as the syringe which is slightly closer, but far away. The next shot of Loki picking up Anna has the syringe and bottles in their original position next to Anna's hair.
Continuity mistake: In the final scene where detective Loki shoots Holly before injecting the poison in Anna's arm, her legs change posture in two different shots.
Factual error: When Hugh Jackman leaves the apartment where he is holding Alex and walks to a store to buy a bottle of liquor the liquor store has signs for beer in the window. The entire movie takes place in Pennsylvania, which only has state owned liquor stores that do not advertise or sell beer.
Suggested correction: I only saw wine and spirits advertised. He also drives his pick up to the store.
Continuity mistake: When Detective Loki is speaking with Keller shortly after leaving his home, Detective Loki can be seen chewing on a toothpick while sitting in his squad car, which disappears in the next shot.