Continuity mistake: When Selene gets to the parking garage, she is wearing her skin tight outfit and is only armed with her guns. But from out of nowhere, she suddenly pulls out a grenade. Her outfit has no pockets and it was not attached/hanging from her outfit.
Continuity mistake: When Selene dodges the flamethrower, her boots go from heels to flats, only to return to heels moments later. (00:06:00)
Continuity mistake: Selene holds an Antigen scientist in his apartment against a huge window by her left hand and asks about Subject 2. The man tries to break her grip and has his two hands around her wrist. The position of the hands differs between shots showing his face and shots from the side. (00:20:50)
Continuity mistake: When Eve wakes up, her white dress has no blood on it. In the next shot, her white dress has blood on it again.
Continuity mistake: At the beginning, when she first unfreezes after her capture she is naked and looks toward her corset and boots in a medicine cabinet. She breaks the glass for the boots first and grabs them. We then see her breaking the glass for the corset, but the boots are still in the glass next to the corset in the lower left-hand corner. (00:09:55)
Continuity mistake: Last scene of the movie on the roof Selene goes through her prologue looking out at the city and she has a bloody mark over her left eyebrow. Eve reaches for her hand and she looks down; when she looks back up the bloody mark is gone.
Continuity mistake: In the secret covenant, the amount of blood on Eve's white top decreases when Olivia the vampire doctor examines her wounds. This is most noticeable under the collar. (00:34:20)
Continuity mistake: When Selene escapes the facility at the beginning of the film and slashes some of the guards' throats with a scalpel, she leaves a ton of blood on the floor and walls, as well as a trail of blood as she slides across the floor. But moments later when we see the bodies on a security camera, all of the blood has disappeared. (00:11:55)