Deliberate mistake: In the final scene when the four cars are driving away there is a road sign that shows how many miles it is to Chicago (where the main characters are from). In reality there would not be such a sign because there is not one direct route from Vegas to Chicago. A typical road sign would show the nearest cities.

Vegas Vacation (1997)
1 deliberate mistake
Directed by: Stephen Kessler
Starring: Chevy Chase, Randy Quaid, Ethan Embry, Beverly D'Angelo
Genres: Comedy
Factual error: After checking-in at the Mirage, Clark is sitting by his hotel room window admiring the northward view of the strip. Based on the view he must actually be sitting at the nearby Treasure Island hotel.
Cousin Eddie: Oh yeah, Yuban Coffee. You know you can sprinkle that stuff on anything? Ice cream, mashed potatoes, or just eat it right out of the can for a quick pick me up.
Question: How much money did the family win after playing Keno?
Chosen answer: $25,000. Given to the Griswalds by Sid Caesar's character just before he passed away.
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Answer: The sign said $30,000.