Revealing mistake: At the beginning of the movie, when Melvin catches Simon's dog, he holds it away from him, with his arms stretched. When the dog begins to pee, you can see that the urine is coming out from Melvin's glove. (00:01:30)

As Good As It Gets (1997)
Ending / spoiler
Directed by: James L. Brooks
Starring: Jack Nicholson, Cuba Gooding Jr., Greg Kinnear, Helen Hunt, Skeet Ulrich
Jack Nicholson finally kisses Helen Hunt, and realizes he forgot to do one of his obsessive-compulsive ticks. He is finally on the right track.
Arnprior
Melvin Udall: Judging from your eyes, I'd say you were fifty.
Carol Connelly: Judging from your eyes, I'd say you were kind, so so much for eyes.
Trivia: Helen Hunt won a Oscar for her role in this movie. Earlier that year she won an Emmy for Mad About You making her the only actress in history to win both awards in the same year.
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Answer: It has everything to do with his mental illness. His OCD condition has kept him isolated with anti-social tendencies. He just finds it difficult to directly interact with people.
raywest ★