Factual error: The movie starts off saying its 2007 and Smart Cars were not sold in the US until 2008.
Continuity mistake: When Sophie is eating the pasta, her T-shirt changes from dirty to clean and then back.
Continuity mistake: When Sophie spits out her food, the mess on Holly's face changes between shots.
Continuity mistake: The day of Sophie's first birthday, just before the arrival of the babysitter the friends are having a toast with juice. When Messer asks "Are you crying? look at the glass in his hand; it's about 1/3 full, same as the rest the scene. Except after the doorbell rings, when Katherine Heigl asks "Why do you need a babysitter?" there's a brief close-up with Messer's chest in frame, and the glass there is about 2/3 full. (00:11:10)
Continuity mistake: In the shot the parents take with her daughter, Messer and Holly when the baby conks Katherine Heigl on the nose, Josh Duhamel's bottle is visible in frame, neck sticking out. Cut, and it's not visible anymore until a couple seconds later, when he is holding it from above. (00:14:20)