Factual error: In the part near the end of the movie where the agents are told that they must push a kill switch to thwart Kitty Galore's satellite launch, Butch says "Look - that red button! It looks like an off switch." Butch is a dog, which means he is color blind. Doubly odd as in the first film Butch does mention that he is colorblind and cannot identify a red wire when he tries to defuse a bomb the Russian cat attached to the lab door. And yet, he claims the whole time that he's colorblind, when dogs aren't actually colorblind anyway. They only have a minor coloring difference, and they have somewhat poor eyesight.
Factual error: The navigation lights on the plane wings used to transport the crew into the fairground are the wrong way round. The red navigation light should have been on the left wing, whilst the green navigation light belongs to the right wing.