Character mistake: While pitching his shrinking machine to NASA Szalinski claims that reducing the size of a rocket's payload would result in "staggering" savings in the fuel required at takeoff. However, he makes it clear that his machine works by reducing the space between atoms, meaning that the shrunken object weighs the same as the original. Weight is the critical factor in calculating fuel consumption, not size. Anyone at NASA would pick up on that instantly.

Honey I Shrunk The Kids (1989)
1 character mistake
Directed by: Joe Johnston
Starring: Rick Moranis, Matt Frewer, Kristine Sutherland, Marcia Strassman
Revealing mistake: In the scene where Amy lets Wayne know that breakfast is ready, she presses a button labeled breakfast. There are other items on the box, such as lunch, dinner, and phone. When they show the board flashing the word breakfast, you can see that the word breakfast is the only word the board can display between flashes.
Russell 'Russ' Thompson, Jr.: Um, dad... You know that weights aren't my thing.
Russell 'Russ' Thompson, Sr.: Weights aren't your thing. Fishing isn't your thing. Just what is your thing?
Russell 'Russ' Thompson, Jr.: I don't know. But I'll keep you posted okay?
Russell 'Russ' Thompson, Sr.: Okay, in the meantime, you're trying these weights, and you're coming fishing with the family! is that clear? I can't hear you.
Russell 'Russ' Thompson, Jr.: Yes sir.

Trivia: In the open-matte print, right after the credits, the support beams of the movie lot walls are visible, painted in blue to simulate the sky. In the theatrical version and the current Disney+ streaming movie's original aspect ratio (bottom picture), one can still see the beams for a split second after the postman puts the letter in the mailbox (though there's no way here to identify them as lot walls).
Question: When Don asks why Russell Sr. won't go on their trip, he says that Mae can't go due to "plumbing." Was he referring to her being on her period?
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Answer: More along the lines of a serious health problem related to her "plumbing".
Greg Dwyer