Deliberate mistake: In Silence of the Lambs Starling was right-handed. In Hannibal she is left handed because we see her writing with her left. Julianne Moore, the new actress who plays Starling is left handed whereas Jodie Foster was obviously right-handed.
Hannibal (2001)
1 deliberate mistake - chronological order
Directed by: Ridley Scott
Starring: Julianne Moore, Gary Oldman, Anthony Hopkins, Ray Liotta
Factual error: At the end of the film, Ray Liotta wouldn't be able to raise his eyebrows as the frontalis muscle had been divided. (01:57:10)
Hannibal Lecter: Tell me Clarice, would you ever say to me "Stop. If you loved me, you'd stop"?
Clarice Starling: Not in a thousand years.
Hannibal Lecter: "Not in a thousand years " That's my girl.
Trivia: At the end of the opening credits, just after "Screenplay by David Mamet" and before "directed by Ridley Scott", look at the right hand side of the screen - you can see Hannibal's face drawn by pigeons. (00:04:25)
Question: Why did Paul Krendler dislike Clarice so much, and why did he ruin her career?
Answer: Starling says to Krendler "Paul, what is it with you? I told you to go home to your wife, that was wrong?", implying that he had made a pass at her and she had rejected him. He replies that it was a long time ago, and that he didn't hold it against her, but combined with Mason Verger's bribe this was most likely the cause of his antagonism towards Starling.
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Answer: In the book it says that Clarice had caught Buffalo Bill before he could. It said also that is why he hated her early in the book.