Trivia: Comedian Paul Rudd had a running gag for many years where, whenever he'd appear on Conan O'Brien's late-night talk show, he'd set up a clip for a film he was promoting... and then instead show the infamous clip from "Mac and Me" in which Eric falls over a cliff in his wheelchair, and the alien Mac pops up in the foreground. The gag ended up going on for 17 years.
Trivia: This film was panned for its blatant product placement, most notably for Coca Cola, McDonalds, and Sears. In the scene in the supermarket, the Pepsi logo on a cooler is whited out.
Trivia: The film ends with a freeze-frame and the words "We'll be back!" superimposed. But after the film failed at the box-office, the planned sequel was shelved. Well, somewhat. There has been some talk about a follow up by RJ Louis.
Trivia: Jennifer Aniston has a cameo as an extra in the McDonald's dance scene.
Trivia: "MAC" stands for "Mysterious Alien Creature".