Continuity mistake: When the kids take Mr. Roth's car, the lights inside the car turns on. When it cuts, the lights are off.
Character mistake: The final scene in which the Hatches leave the overpass that they take shelter under in the final tornado has the family walking off as the sun has risen. Jack states in his narration that the tornadoes occurred over the span of three hours, thus creating an incorrect timeline as the events leading up to the tornadoes hitting Blainsworth take place in the evening; the Grand Island outbreak does take place over three hours, however all seven tornadoes touch down between 8:45 and 10:45 p.m.
Continuity mistake: When the two cars with the family inside leave their destroyed house towards the end, both cars have the back light that shines on the license plate on, the next shot one of the car's light is on, and in the shot after that both cars' lights are on.