Continuity mistake: The image of "Che" Guevara hanging from the rear-view mirror keeps appearing and disappearing during the first part of the road trip, right before it is substituted by the toy rabbit Luisa buys at the township.
Continuity mistake: The movie takes place in the summertime - we know this from the boys just having graduated, their girls going off to Europe, the weather, etc. Yet at the wedding near the beginning of the film, the narrator tells us that in a few days the president of Mexico will go to Seattle for the WTO conference - which we all know happened in November.
Factual error: Ana's mother, "a French divorcée," according to the movie, teaches at cepe, which is a college within the National Autonomous University of Mexico specifically for foreign students. However, I attended cepe, and non-native Spanish speaking teachers would not have been allowed to teach there, as the entire point of cepe was to introduce the Spanish language and Mexican history/culture to foreign students.