Factual error: When John Belushi, Wendy-Jo Sperber and Treat Williams are on the stolen motorcycle, Belushi gets mad, pulls a pin, and disconnects the sidecar from the motorcycle. This is not how sidecars are actually attached or they wouldn't go the same direction as the bike.
Factual error: In the beginning, a submarine surfaces. The area is supposed to be off the coast of California. A large rock is seen which is obviously Haystack Rock, a tourist destination off the coast of Pacific City, Oregon.
Factual error: When Frank Mcrae and John Candy are arguing in the tank, Candy gets covered in soot when the exhaust manifold blows. This couldn't have happened as the engine in the tank is in the rear of the vehicle and it's separated from the crew.