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Continuity mistake: As Raoul is being chased by the highway cop, the camera switches views between the rear view and looking through the back window. The line in the middle of the road changes unevenly between passing and no passing lanes.
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Continuity mistake: When Gonzo is trying to kill himself in the bathroom, there's a watch behind him that appears and disappears between takes.
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Visible crew/equipment: When Duke leaves the Mint Hotel and drives in the desert, the camera frames on a big cartel that reads "Welcome to Fabulous Las Vegas Nevada." Its shadow is projected on the road and with it also the shadow of the camera crane that shoots the scene. (01:01:24)