Revealing mistake: When the girl is giving the guy a blow job in the school restroom, he finishes in her mouth. She goes to the sink and spits it out. You can obviously tell she had a mouthful of water going by the color and quantity. (00:20:45)
Revealing mistake: John has to cut off his hand so the virus won't spread. Afterward, Cassie uses duct tape and wraps his stump up and you can see he is making a fist under the tape. (01:08:10)
Character mistake: When John and Cassie are in the school library and look up about the disease, the book caption reads: "arm amuptation." The word amputation is misspelled.
Answer: Spoiler Alert: At the end of the first movie, Paul was not safe at the hospital. The doctors inform the sheriff that Paul needs to be transferred. We then see Deputy Winston take Paul, but instead of transferring him, Winston dumps Paul on the side of the creek. In the 2nd movie, Paul is alive, but just barely as he's badly infected. He's trying to get help and finally manages to make it to the highway, where he gets hit.
Bishop73