Continuity mistake: Walter near the beginning of the film, is going over the ship's systems. He checks the fetuses inside a compartment and sees a dead one. As he removes it, the slot it came from is full of blood. He places it inside a container. Then as he hits the button to close the compartment, the slot has no blood in the next shot, and no implying he cleaned or decontaminated the slot. (00:08:00)
Visible crew/equipment: As they notice something large pass through the woods, the camera pans from left to right You can see a blinking light to the right of the waterfall in the distance on the lake, which is something in the park in New Zealand. (00:36:50 - 00:37:30)
Suggested correction: The flashing light actually belongs to the rotating beacon light on top of the shuttle. This light is shortly after when the crew start to return before it explodes.
Continuity mistake: When two of the crew members stay behind to take samples, she closes the sample and hands it to him, but in the next shot, he closes it again. (00:38:00)
Continuity mistake: When Tennessee walks in, the Jack Daniels bottle on the counter is empty, seen from several angles, then she pours him some in a glass. (01:41:00)
Continuity mistake: Daniels' face gets splattered with blood, in a following shot there's slightly less blood, then when she uses the radio to call back the others, her face on the screen shows no blood at all. In the other shots after it's there again.
Character mistake: This ship's computer, 'mother', says "declention" instead of "declination" when giving coordinates of the planet.