Factual error: The exterior shots of Rusty's plane show a Boeing 777, a modern twin-engine widebody with a distinctive square tail (and glass display panels in the cockpit). The cockpit interior scenes shows a mishmash most closely resembling a vintage 727, with three columns of individual gauges for each of the three engines, among other details, including small "eyebrow" windows above the main windshields. Later Rusty says he flies an Airbus A318, which is totally different from either Boeing.
Factual error: When the family leaves their house to start the long road trip, they show a nice residential area with downtown Chicago in the background. This is not possible. The view and angle at which they are showing downtown is the same image that one would see from the Adler Planetarium. At the angle at which we see downtown Chicago could only be from the Adler Planetarium and there isn't anything even resembling nice residential homes in that area. Also, the area looking at downtown from that angle is mostly water-Lake Michigan and boat docks. In other words, looking at the Willis Tower (Sears Tower) from the Adler Planetarium, it would be 60° off due north, an extreme angle putting the family house either in or very near the water (Lake Michigan). (00:18:25)