Continuity mistake: When driving the silver Audi A6 the first time, the version they are driving is a diesel, seen by the exhaust pipes facing down towards the ground with a bend. In the next shot they are driving the petrol version of the same A6, seen by the exhaust pipes holes facing directly out from the car. (01:18:33)
Character mistake: There are signs out front as the Spenglers arrive at the dirt farm. One of the signs is a call back to a scene in Ghostbusters 1984. In the scene, Ray quotes the book of Revelation: "And I looked, and he opened the sixth seal, and lo, there was a great earthquake. And the sun turned black as sack cloth, and the moon turned blood." When Finn Wolfhard reads it he misquotes the line saying "The sun became as black as cloth."
Deliberate mistake: In the Spanish release, the name of the family store is written in Spanish, but inside the place it's in English everywhere. This is a very common mistake in foreign kids' films released in Spain.
Continuity mistake: When the Grand High Witch kills a witch, there's a broken lectern on the floor. When the dead witch bolts backwards, the broken lectern disappears.