Trivia: Spoilers! Red Skull makes his long-awaited return to the MCU after his appearance in Captain America: The First Avenger. We discover that he's been guarding the soul stone as punishment, of sorts. However he's played by Ross Marquand, not Hugo Weaving.
Trivia: When Ralph and Venellope arrive in the internet they are bombarded with pop up ads. One of those ads features a picture of a woman with short brown hair. That woman is Aunt Cass from the Disney animated film, "Big Hero 6." In addition, Baymax from that movie makes a cameo appearance at, "Oh My Disney!"
Trivia: The Philosopher's Stone from the first Harry Potter film is visible inside Nicholas Flamel's locker.
Trivia: Lewis' new friend, Rose Rita, is the main character in other books by John Bellairs, author of the original novel.
Trivia: The way Donna attempts to get the bus stopped is a direct nod to the 1994 movie Speed. The bus driver is even named Sam, the same as the driver in that film.
Trivia: Even though Morgan Freeman is top billed, he has only six minutes of screen time.