Continuity mistake: When Nick is sitting on the bed talking to Jessica, her position changes from lying on her side to lying on her back, as the camera angle changes.
Continuity mistake: At the start, Robert Neville drives into some yellow poles, only to drive into them again in the following shot.
Continuity mistake: When Sam and Mikaela handcuff all the agents, Sam is wearing a black short-sleeved tee shirt atop a blue long-sleeved tee, before putting on the hoodie. We see the dark tee sticking out when he and Mikaela climb onto Prime. Then moments later, Sam is wearing ONLY a long white short-sleeved (we see it has short sleeves when Bumblebee gives him the All Spark later, through a tear in the hoodie sleeve) tee shirt under his hoodie, when he falls from Prime, when he witnesses Bumblebee's capture and thereafter. (Earlier, after he knocks Mikaela off the moped, from that point on there is a very large hole at the back of his blue and black tees, where we see his skin under the jagged material edges, with no white material seen anywhere. We also see no sign of a long white undershirt at any time when Sam's dark tees go up, during his many action shots.)
Continuity mistake: During Sandman's attempted heist of the armored truck, he punches Spider-Man through the side of the truck, and the damage to the armored wall significantly changes in the following shots.
Continuity mistake: The birth of the Predalien in this movie is completely different than it was in the first AVP. The lights on the table are different and the Predalien bursts out differently than in the first film. (00:01:30)
Continuity mistake: After the Zombies are unleashed in the desert scene, we see Carlos crawling under the truck. At first his semi-automatic gun seems to be completely normal. The gun's slide and chamber are closed as if there are still bullets in the magazine or at least one bullet is chambered. But then the camera focuses on his gun and we see the gun's chamber is open - as if there are no bullets left. The gun didn't fire between shots so it's chamber should have been open in the first place. (00:58:10)
Continuity mistake: Mike avoids colliding head-on with a pickup by swerving off the road into a farm field. He does this after passing a tractor and flatbed truck to his right. The shot changes and he is turning off the road into the field between the tractor and truck. (01:36:50)
Continuity mistake: When the tentacle monster rips out a chunk of Norm's chest, a large spray of blood splashes on his right-side jaw and cheek. In every subsequent shot of him, this blood is gone and his jaws are completely clean. (00:26:30)
Continuity mistake: When Ben and Gwen are fighting off aliens on Incarcecon, right after the tetramand destroys the hoverboard, the Omnitrix is missing from Ben's wrist.
Continuity mistake: During the scene where Lewis is first on the roof-top, and Mildred comes up to speak with him, the box he is sitting next to is plain wood on one side, and tallied on the other. When there is a close-up of Lewis' legs and the torn paper, when he's ripping the pages out of his book, the box has stencilled writing that is upside down. (00:06:25 - 00:18:30)
Continuity mistake: In Metropolis on the bridge, Doomsday grabs a soldier and breaks his neck and skull. In that shot, the soldier's arms are inside Doomsday's hand and his hair is a light brown or gray. But then when the shot changes as Doomsday begins to throw the soldier to the side, the soldier's arms are suddenly outside of Doomsday's hand, and his hair is now black. (00:17:10)
Continuity mistake: In the hybraxi, Al Gore's blazer is blue and he is wearing a red tie, but in the next shot, it is brown and he has no tie.
Continuity mistake: When Cillian Murphy's character is recording his message prior to entering the 'dead zone', our viewpoint is from within the monitor in front of him. As such, we see the on-screen image he sees, but reversed, floating between our vantage point and his image. At the bottom of the screen are touch-screen function 'buttons', again in reverse, which read (our left to right) 'RECORD', 'SEND', 'DELETE' and 'REVIEW'. But when our view changes to see the screen as we look over his shoulder from behind him, the visible buttons now read (right to left) 'SEND' and 'REVIEW' (he presses 'SEND'). They should be 'SEND' and 'RECORD'. (00:06:15)
Continuity mistake: When the helicopter plummets into the wedding terrace, its nose is either pointing the right side or the left, depending on the shot. No continuity at all.
Continuity mistake: Shoeshine is telling Jack to 'give the dog your food'. Jack throws him a rubber steak, which moves further away from Shoeshine in a subsequent shot. (00:35:00)
Continuity mistake: When Andy gets sprayed with blood at the virus outbreak scene, when a sniper saves his life the blood splatter changes several times over the movie. (00:54:15)
Continuity mistake: The train that Carol takes from Washington to Baltimore is an Amtrak Acela Express train, as can be seen in the station and interior shots. The exterior shot of the train passing by shows a different type of Amtrak train.
Continuity mistake: In the beginning of Part 3, Ryan Reynolds is on a deserted two-lane highway asking Hope Davis for help. She refuses to help, begins to turn and walk away down the double-yellow center lines of the road. In the next shot, we see her finishing the turn and walking on the edge of the road, by the white line (facing traffic). Immediately after, she is shown on the right side of the road, on the other white line (walking with traffic). (01:14:15)
Continuity mistake: In the scene where Henry is pouring the whiskey into the cups, the bottle is half empty when completed. Next scene Henry is nursing the bottle which is now almost full. (00:06:00)
Continuity mistake: When Frylock is watching New Jersey getting destroyed by the Insane-O-Flex, look for a building to the left through the Ferris Wheel. When Meatwad transforms into a building, the fires briefly stop, then turn on again.