Revealing mistake: After Steven Wilkins disguised as a vampire kills the unnamed woman he closes her eyelids to make it look like she's asleep. Just before his hand contacts her eyelids you see her almost blink, revealing she's very much alive.
Revealing mistake: When the taxi goes over the edge to capture Dr. Neville, you can see that the underbody of the car as it goes over is a flat painted surface and not the underside of what should be there (i.e., muffler, gas tank, etc.).
Revealing mistake: As Carlos is giving his final goodbyes to Claire you can see in the background automobiles driving down the freeway. Shouldn't these roads be empty rather than having what seems to be a thriving highway? (01:10:00)
Suggested correction: Not a single car in the background.
Revealing mistake: In the beginning of the movie, when Michael removes the knife from the drawer, you can see the blade bend.
Revealing mistake: During the heavy snowstorm, the telephone wires are still, even though it's a blizzard.
Revealing mistake: The quick shot of the Bible landing in the drawer is reversed. (00:29:20)
Revealing mistake: During the scene where the military loses control of London, and their snipers are told "all targets are free", you can see heavy padding beneath Infected/civilian victims' shirts, etc, as they're shot. Presumably it's to stop them injuring themselves when they fall over, or to hold apparatus for the blood effects, but it's too bulky to be part of the characters' clothing.
Revealing mistake: On night 21 the time-stamp changes from 11:59:56 PM to 11:59:57 AM despite it not having turned midnight yet.
Revealing mistake: When Laura falls in the bathtub, a stunt is doing the fall, because her hair colour and style changes.
Revealing mistake: When Art is hitting the Trevor (the blinded man) character with the hammer/hatchet in the beginning, if you look closely, you can see blood coming from Trevor's head, yet there is no wound or cut. The blood is actually coming from the prop that is hitting him in the head. (00:09:00)
Revealing mistake: During the bidding, the girls' pictures on the phone are obviously super imposed images and not really the picture phone screens.
Revealing mistake: When the zombies are eating the intern in the hospital, you can see one of his ribs move as if it were made out of rubber. (00:51:20)
Revealing mistake: When Jake is being tied up, he's holding his hands up to make it easier for the cannibal to tie up. Also when they drag him out of view, he's holding his head up so it doesn't drag the ground, although he's supposed to be unconscious during all this.
Revealing mistake: Sean Patrick Flanery plays a nerd who has trapped a female vampire in a cage. About 3/4 of the way into the movie, he tricks a co-worker into visiting, planning to feed him to her. He extends his right arm through the bars, and she starts to caress and kiss it, then begins to bite it and suck his blood. When he tries to withdraw, she tears off his arm at the shoulder. But in the next shot, he and Flannery both hit the floor outside the cage, and the co-worker's right arm is visible. However, when the scene begins, both Flanery and the co-worker are wearing watches on their left wrists, and in the shot of them on the floor, both have watches on the right, suggesting that the image has been reversed.
Revealing mistake: The opening shot of the movie shows a rabbit hopping up from the bank of a road and then being hit by a car. You can, however, tell that the rabbit is not real because as it moves up the bank, none of the grass moves as the rabbit bounces through it. (00:01:05)
Revealing mistake: At 39:55, actress Jaime King gets out of the shower, and she has just reached for her robe, and then on the bottom right corner of your screen you can see a bit of the flesh-colored body suit she's wearing. Continue to 40:00 where you see it again. Continue to 40:05-40:09 where you can see it, without slowing or stopping frame. (00:39:55)
Revealing mistake: During Ian's double-kill moment in the morgue, you can see the prosthetics on his chest crease once he drops to his knees for the fatal blows. (01:14:00)
Revealing mistake: At the start when the tree falls through the window, it's been pushed through the window horizontally. Since it does no damage around the window as you would certainly expect from a tree falling through an arc. (00:01:20)
Revealing mistake: When the dark-haired kid's hand gets cut off, no blood is ever seen spurting from the stump. (00:07:25)