Plot hole: It seemed to take the police an awfully long time to get to the hospital once it was taken under seige. It seemed to take the camera man an excess of 10 minutes to realize something was wrong. After John took the camera out it was another estimated 15-25 minutes before the police came. I find it hard to believe that the police would be that slow to get to a hospital and that the camera operator would take a few minutes before phoning something in.
Plot hole: Clint Eastwood's whole investigation/solution is based on him suspecting that the victims had a common tie, rather than being random. The problem is there is no reason for him to think this - there is no reason given for them to not be considered random victims. For him to think otherwise was a bit far fetched. In the book, however, they were all on the organ donor list, which led him to the fact they all had the same rare blood type and so on.
Suggested correction: Not really farfetched. It's a common plot device for a cop to look for a link. When he finds out Gloria gave blood, he remembered the sticker in the other victim's car.
Plot hole: When the FBI finds out that Dolarhyde knows where Graham lives, they send a chopper and some agents over to Graham's house to pick up his wife and son. His wife is startled by the noise of the chopper SUDDENLY appearing without any warning. How could she have not heard the chopper approaching or seen the light?
Plot hole: When Hundert hits the ball into the window of Mr. Woodbridge's car he keeps standing there for a moment with the club in his hand while the boys run away. Woodbridge looks in his direction and should have seen him, however, he starts asking around who the culprit was. (00:44:20)
Plot hole: How can they have gotten confirmation to launch the missile from Moscow if the insulation on their transmitter was damaged? If it was a separate transmitter, why not use it in some way to contact Moscow during their crisis?