Trivia: The idea of having the bath house workers clean the river spirit came from an experience Hayao Miyazaki had when he was younger, where he helped clean a polluted river and one of the items removed from it was a bicycle.
Trivia: The voice behind Roz, the number 1 of the Child Detection Agency and the undercover secretary, is actually a man.
Trivia: Jimmy's dog is named Goddard. American physicist and inventor Robert Hutchings Goddard (1882-1945) developed the first liquid propelled rocket engine in 1926.
Trivia: In the widely released version of Osmosis Jones in the background of the opening chase scene, a remix of Foreigner's 'Hot Blooded' plays, but in the VHS release it plays Electric Avenue by Eddy Grant.
Trivia: Back when the movie was in the pre-planning stages, the story was supposedly going to revolve around the GS Ball, which Ash and company carried all throughout the Orange Islands and 1/3 of the way through Johto. Evidentally, the GS Ball was going to be finally opened to reveal that Celebi was hidden inside. This may have been the movie's plot had Pokémon Crystal not come out for the GameBoy Color.
Trivia: During the sequence with the explorers' huge submarine submerging, one of the computerized "extras" can be seen waving at the camera. (He is seen through the lower window for only a second or two; use frame advance to view it or listen to the Visual Commentary on the DVD for specifics). (00:16:39)
Trivia: In every Final Fantasy video game, and the movie, there is a person named Sid (even though sometimes it's spelled with a 'c').
Trivia: The way the god of sleep's goat legs were achieved usually consisted of hiding the actor's legs behind or below whatever the character was sitting on. However, when he had to walk, the actor wore a pair of green screen pants with the goat legs going down to his knee. There was padding from the bottom of his knee to the top of his foot so he wouldn't make any sound he wasn't supposed to. Look behind him when he walks in a crowd and you'll see that nobody gets less than two feet behind him. This is most noticable in the slumber party scene and when monkeybone steals Stu's exit pass. To see what I mean, look at the special features and watch "The Secrets of Monkeybone"
Trivia: Near the end of the movie, a teacher yells, "Hey teacher, leave those kids alone." A clear reference to Pink Floyd's song "Brick in the Wall".