Factual error: In a number of episodes people are shown eating and drinking in the laboratories. For instance, in "Miss Willows' Regrets" Nick and Greg are seen eating fried chicken in the lab, and in "Overload" Sara eats a sandwich while watching Grissom experiment with her deli pickle. There are other examples. No reputable laboratory (which this is supposed to be) would allow its staff to eat or drink while in the lab. It is basic scientific protocol to prevent contamination of samples or the person picking up toxins on their food.
The Best Years of Your Death - S1-E3
Plot hole: In the chapel, you can see the heads of those who tried to cross Harriet (the mad matron) preserved in formaldehyde. How did she get hold of so much of it? Wouldn't her husband or the headmaster be suspicious?
End Game (1) - S8-E7
Revealing mistake: Boyd has a video-conversation with Linda on the phone she sent him. On top of the screen you can see how long the video will last (1 minute and 3 seconds), showing it's a pre-recorded video, not an actual live conversation.