Revealing mistake: It's painfully apparent that the actors are hung on wires pretending to swim while outside the sub.

Fantastic Voyage (1966)
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Directed by: Richard Fleischer
Starring: Donald Pleasence, Raquel Welch, Edmond O'Brien, Stephen Boyd
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Wireless Operator: A test message from the Proteus, sir. Miss Peterson has smiled.
Col. Donald Reid: Well, that's an auspicious sign.
Question: Just an observation. There's 5 or 6 minutes of screen time between the initial shrinking of the sub / crew and the start of the 60-minute clock. Shouldn't those minutes have been included in the countdown?
Answer: The sub was shrunk in stages, with the lab personnel performing different tasks at each step. The clock automatically reset after each step was completed and as the next shrink phase commenced. The final sixty-minute countdown began after the last shrinking stage and when the sub is injected into the scientist's body.
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Answer: I think the countdown began after the crew were injected into the patient's body.
No, the countdown started after the second shrink.