Trivia: The bar "Mahoney's" is named after the late John Mahoney, who played Frasier's father in the original show.
Trivia: Willa is played by Timothy Olyphant's daughter Vivian.
Trivia: The name on Jenkins' disguise is "Chuck Spadina." When Keanu Reeves first came to Hollywood, he was told his name was "a little too exotic," and it was suggested he should change his name. Chuck Spadina was one option he considered, although apparently not very seriously.
Trivia: Ashley Johnson plays Anna Williams, the mother of Ellie. Johnson voiced Ellie in the video game the show is based on.
Trivia: S01e9, "Bitter Sweethearts", features Tom Arnold playing Arnie Orwig. Tom Arnold starred in the "True Lies" film. The name Arnie could be a reference to his "True Lies" co-star Arnold Schwarzenegger (who is sometimes called Arnie") or his "Roseanne" character, Arnie Thomas.
Trivia: Charlie (Milo Ventimiglia) is asked to help break someone out of prison. He says he doesn't do prison breaks. Listening in on the bug Charlie is wearing is his sister Birdie, played by Sarah Wayne Callies. Callies starred in Fox's Prison Break.
Trivia: Jennifer Hale is taking over the role of Jean Grey from Catherine Disher. Hale previously voiced Jean Grey in Wolverine and the X-Men. She also previously voiced Felicia Hardy/Black Cat and Julia Carpenter/Spider Woman in the 90's Spider-Man and Iron Man animated series, respectively, which take place in the same continuity as this show.
Trivia: Lars Mikkelsen, who plays Grand Admiral Thrawn and voiced him in Star Wars: Rebels, is the older brother of Mads Mikkelsen, who played Galen Erso in Rogue One: A Star Wars Story.