Character mistake: The doctor diagnosing Will's illness tells Evelyn and Max that it's caused by "an isotope called polonium." Polonium is a chemical element, not an isotope. The word "isotope" refers to a form of an element (such as carbon-12 or carbon-14) not the element itself. It does not mean "radioactive substance", because many isotopes are stable. A doctor would know this. (00:17:00)
Character mistake: Shortly before the drone chase scene Cooper tells Murph to put the truck in second gear. She pushes the gear lever forward, however on the 6-speed manual in the Ram 3500 second gear is in the back row.
Character mistake: During communication with ATC the co-pilot states their call sign followed by the read-back of ATC instructions. This order is incorrect. In reality a pilot or co-pilot reads back the instructions from ATC and then their call sign or tail number prior to ending their transmission.