Revealing mistake: When Anna and Hans are dancing in front of the lighthouse, we don't see the shadow of the railing or the ground they're standing on.
Continuity mistake: When Tom the Minion dressed as a maid is hoovering, he answers the front door by opening it towards him as does the minion who looks out of the door after Tom has been taken. In the scene with Gru sat on the steps in the rain, sad that Lucy is off to Australia, Agnes comes out with an umbrella, but now the door opens outwards.
Continuity mistake: In the scene where Grug is chasing after Guy, they both wind up stuck in a tar pit. After successfully escaping they are covered in tar and Grug even gets himself stuck to Guy. In the next scene everyone is running from the exploding ground up between the mountains and both Grug and Guy are completely clean and free of tar.
Continuity mistake: Lotte barges in the pizza place and carves her name onto Shaggy and Scooby with her sharp nails. LOTT on Shaggy's shirt, and the E in Scooby's fur. They run out the door and then come back to pay for their food. Suddenly the rips in Shaggy's shirt and the scraped off fur on Scooby's chest have vanished. (00:23:45)
Other mistake: Sam draws an orange vest for Lockwood using a dark crayon. (01:10:45)
Continuity mistake: After Batman shoots Reverse Flash through the head, Flash rushes over to Batman and catches him before he falls over from his wounds. As Flash is lying him down slowly, there is no blood on Batman's face. It then cuts to a close up as Batman reaches up to pull off his mask and there is suddenly blood on his lips and chin. (01:12:20)
Plot hole: When Jake first meets Reggie, he tells Reggie that the Great Turkey told him everything about him. Later in the movie, when Reggie goes back in time and introduces himself as the Great Turkey to a young Jake, he only tells Jake to find the "Pardoned Turkey" but never said that the pardoned turkey's name was Reggie, so there's no way the adult Jake would know Reggie's name when they first meet.
Continuity mistake: In the scene when Mike is at the school door lab. When he swipes the access card the door swings out. But when the campus police try to get in it is blocked from the inside, indicating the door opens inwards.
Suggested correction: If you look carefully, you will see, that those are actually two different doors, which even have hinges on different sides. There's some space between them in the entrance to the lab, it can be seen just before Mike enters.
Continuity mistake: Towards the beginning of the movie, Gerry's son spills hot coffee all over Gerry's shirt. He is wearing a white shirt/vest for his uniform. There is no stain or even wetness left behind.
Continuity mistake: When Dusty first takes off for the big race his "D7" on the right side of his tail disappears. (00:32:35)
Continuity mistake: In the hotel, at Gagamel's room when Clumsy suddenly opens the food lid and bonks the room service guy. The lid falls at the right side of the door, but in the next shot, when Gagamel opens the door, the lids is on the left side. (00:55:55)
Continuity mistake: As Lex and Joker are talking on the bridge between two towers of Arkham Asylum, Joker is shown standing in the middle of the bridge. But when the guy on the intercom announces there is an escape going on, the camera changes angles and suddenly Joker is right next to the edge. (00:19:20)
Continuity mistake: After the failed attempt to drop a mace on Mr. Ginormous' head, the giant grabs Jack, Tom, and Jerry and taunts them. He then throws them onto the table and Jack's hat comes off and flies away from him. Shot changes angle to Jack trying to sit up and pop off at Ginormous and suddenly his hat is right next to him. (00:43:15)
Audio problem: When Tony is telling Pepper about what happened to Rhodey, there is one shot of the side of Tony, slightly to a back angle where he is talking. His jaw does not move at all while speaking during that shot. (00:27:10)
Factual error: When Braniac's robot probe enters the atmosphere over Arizona, fighter jets attempt to shoot it down by hitting it with missiles. The pod is still going fast enough to be on fire from reentry. A missile could not have caught up to an object going that fast. (00:11:30)
Continuity mistake: As in most movies I've seen where size is a main factor, the animators did not pay much attention to scale. In the scene where the main character leads the leaf people to her father's house, she is jumping and lands on the thinnest pencils I've ever seen. They have the width of the pencil smaller than her foot. However later on, it is shown that a push pin is almost the size of her body.
Continuity mistake: When Turbo is about to go down the curb after nearly getting killed by the lawn mower, you see him lined with the 2, he's on the left side of the 3.
Continuity mistake: The Appraiser puts the condemned tape across Dorothy's wrecked porch. The tape from the bottom right to the upper left is the one in the front of the other diagonal line, but then it's the other way around. (00:07:30)
Plot hole: Luka sneaks into Bayonetta's hotel room and plants a hidden microphone. While sneaking out, he is caught. That's when he is astonished to find a child with Bayonetta who calls her "mummy." He does eventually escape the room and sits in corner with his radio, surprised that they both went to bed and he receives nothing. The problem is: One must be an idiot to plant a mic in a lone woman's hotel room in the dead of the night, unless he truly enjoys listening to her snoring! Planting the mic in her apartment or office, or on her mobile phone makes a lot more sense.