Trivia: When Megamind as Bernard is in the library with Roxanne, the book he is reading ("Megamind Unmasked") has a description on the back of a self-help book entitled "The Happiest Me I Can Be". This is the same book that Metroman read (shown later in flashback) that caused him to decide to cease to be a hero. (00:43:30 - 01:08:30)
Trivia: The creature that hunts down the Doctor before being shot down by the Sniper girl is actually the original design of the Predator that was scrapped during Predator 1 due to issues with the costume and the jungle. The original Predator was supposed to be very slender with backwards knees and long arms, but because of the jungle setting, it was scrapped because the director was unable to make the costume work properly.
Trivia: During the film's climax, a young boy in an Iron Man mask is shown standing up to one of the Hammer drones with Iron Man swooping in and destroying the drone and giving the kid the credit. Following Spider-Man's inclusion in the Marvel Cinematic Universe, a fan theory suggested the young boy was Peter Parker, which Marvel Studios President Kevin Feige and Spider-Man actor Tom Holland would later retroactively confirm.
Trivia: The two 'disc jockeys' in the soundbooth of the 'End of Line' club are actually Daft Punk, the French group that created the movie's soundtrack.
Trivia: In the opening scene with Richard Dreyfuss fishing on the lake he is singing to himself "show me the way to go home". This is a nod to the movie Jaws because it is the song that he sang along with the rest of the crew as they waited for the tagged shark to be re-sighted. (00:01:00)
Trivia: When the foursome ski down the mountain and are looking around at the oddly dressed people, someone behind John Cusack says, "Hey Lane, you owe me two dollars". This was a nudge to John Cusack, who played Lane Meyers in "Better Off Dead" and was pursued in the snow by a crazed paper boy shouting "Two dollars!"
Trivia: Leon Kennedy, a popular character from the games, was originally intended to be in the film but was dropped. He later appeared in the fifth film.
Trivia: Some of the crew members and background extras were also a part of the film "Repo: The Genetic Opera", which has a similar premise. Story goes that Universal wanted to make "Repo", but backed out after the producers refused to meet their demands. (Universal execs reportedly wanted to remove all the musical numbers from "Repo", even though it was by very design a rock-opera.) After leaving the project, Universal then announced this film (then titled "Repossession Mambo") and reportedly approached cast and crew members from "Repo" to come over and work on this film. The creators of "Repo" have made it clear that they feel Universal was merely trying to spite their production by poaching cast and crew members who were unaware of the falling-out between "Repo" and Universal execs.
Trivia: At the beginning of the movie Markus Kane is watching TV with a woman, the show that he is first watching is Death Race 2000 before changing the channel. Death Race 2000 is what the Death Race movies are based off of.