Continuity mistake: Rumpelstiltskin looks completely different in this movie than he did in the previous film Shrek The Third; Prince Charming momentarily talks to Rumpelstiltskin in the tavern during the third film, and the character looks completely different, has a different voice and different demeanor.
Continuity mistake: During Andy's daydream at the beginning of the film, Mr. Potato Head has an eye patch over his left eye. When the daydream cuts back to reality we see that Andy has removed Mr. Potato Head's left eye to symbolize the eye patch. But when Andy's mum comes in with the video camera, his left eye is suddenly back in. (00:01:15 - 00:05:25)
Plot hole: When Astrid gets on Toothless for the first time, Toothless takes off uncontrollably and tries to scare her. Hiccup seems to have no control over him at this time. How is that so if with the new tail fin, Toothless cannot fly without Hiccup's precise control of the tail fin? That whole sequence would have fallen apart. This mistake was even admitted to on the DVD commentary. (00:53:35)
Continuity mistake: Just before Flynn cuts off Rapunzel's hair, there is a shot from behind him and he reaches up with his right hand to push her hair behind her ear. His arm is visible up to his forearm and the shackle is nowhere in sight. However, in the next, wide shot, the shackle is suddenly up around his wrist. (01:01:20)
Other mistake: When the ride finishes, there is no sign of a safety bar in Gru's cart.
Continuity mistake: Whenever Megamind or Minion uses the disguise generator, their normal eye colour always show through their disguises, such as when they both disguise themselves as the Warden (the Warden has blue/gray eyes while Megamind has green and Minion has brown). However, during the final battle, Minion disguises himself as Megamind but he has Megamind's green eyes instead of his normal brown eyes.
Continuity mistake: In the second scene where we first meet ranger Smith he is shuffling with some information pamphlets. When Ranger Jones yells his name he is startled and drops some of the pamphlets, but we can see that the last ones he put in were on their side. When the camera changes shots there appears to be some pamphlets sticking out. Then in the next shot they are gone. The pamphlets change locations between shots.
Continuity mistake: During the last fight with Darkseid, there's changes to what the farm looks like. At one point, instead of the windmill there's a building, which we never saw when Clark drove past the spot. And the overturned truck is missing in a several of scenes even though it should be visible.
Continuity mistake: In the final battle scene after the Band reaches the canyons and are on a cliff overlooking the Guardians, you can obviously see that Twilight doesn't have his lute. After focusing on Soren struggling to remove the pot of tar, we see Twilight flying with Digger and Gylfie, but with his lute. Impossible to be so fast. (01:11:55)
Factual error: If there was that much of a famine in the pack, the Omega wolves would surely have already died of hunger.
Continuity mistake: Jason spits blood onto Joker's chin which changes spot wise and shape wise by the next shot.
Continuity mistake: In the beginning, when Billy is talking to the bum (who later turns out to be Tawny), the bum has a glove on his right hand. When he reaches his right hand out to Billy and Billy gives him a subway token, there is no glove. It's back in the next shot.
Audio problem: When Niko is going to get the key for somewhere for Zoe to hide and then Zoe disappears he says "Zoe"? When he says it his mouth does not move but once he finishes saying it that's when his mouth moves.