Plot hole: In the scene where she goes to her house after escaping there is no police tape on the front door even though it is a crime scene. Earlier the police searched and taped her office - it only makes sense that they would do the same to her house.
Plot hole: The fearless trio is in the watch tower when the hillbillies set fire to it. Realizing their fate if they stay, the three then jump out the window and onto nearby tree branches in order to escape the blaze. After escaping the towering inferno, it seems that the fire dies immediately. These three don't go far after jumping and are in the trees for some time. Shouldn't there be a great glow and lots of noise and smoke from the fire as the watch tower burns down? (00:53:45 - 00:56:00)
Plot hole: In the institute, Will's friend gets out of his room to get the guard's keys. He couldn't have gotten out of his room because there isn't a handle or door lock inside the room.
Plot hole: When the innkeeper is asked by the rich ex-actress to give her the key to a nice room, he gives her a key telling her that eight is cozy and the key has an 8 on it as well. But a few minutes later, when this woman is about to be murdered, she leaves her room (holding her mobile phone) and the door has a 9 on it. How can a key to the room 8 open the door of the room 9? [Still a mistake, but there's an explanation. In the DVD extras you can see a deleted scene in which she changes rooms because she wasn't happy with 8.]
Plot hole: How did a woman who had just escaped from a mental institution get out of the country so fast? Even if she had a passport already, she wouldn't have it - the hospital or her family would. How could she get it back from them without SOMEONE turning her back in to the institution? It takes a lot to get involuntarily committed in the US, and I doubt she could get un-committed that fast, even with the guy she tried to kill vouching for her.
Plot hole: Even assuming that creating a manhole underneath your own feet Looney Tunes-style shooting a gazillion bullets around you through the floor is a better battle strategy than using said bullets to shoot at the three remaining wolves charging at you in the small corridor, said creatures don't suddenly stop existing just because you fell down one floor, making their complete disappearance - they do not give chase through the hole or stairs nor even make as much of an angry sound throughout the rest of the scene.
Suggested correction: I think this is more a stupidity than a plot hole. She could have escaped or defeated the wolves in any kind of ways, it's not a plot hole that she escaped by using a tactic that is illogical but not impossible.
I would absolutely agree about the silly tactic itself, but there were pursuing werewolves in that corridor, and for the remainder of the scene she just faces Lucian. There's no explanation why they don't come through the same hole, or take the stairs, or claw a hole through like they seemed to easily do in Michael's apartment.Not even a snarl: she drops one floor and they are...gone? So that part feels like a plot hole to me.
Plot hole: The truck was in front of all of them when they turned on with the green light, but it passes them when they are stuck with the red truck. So the crash happens moments past the light, so they would all be way past that point on the interstate.
Plot hole: It shows two air tanks missing on the boat. Now obviously when they get back to shore and all the tanks are put back, there would be two empty spaces, meaning hey, we forgot two people.
Suggested correction: True, but who says they didn't alert the authorities or return when they eventually realised it? Even if they did, the two divers drifted and were being stalked by sharks. It was set up earlier in the film when they showed their flawed way of tracking who went into the water and returned, so it makes sense that they overlooked what happened. There's also a scene when the boat returns where an employee notices two missing tanks, so they did notice it.
Plot hole: Everyone is by Jack to try to help with the alien monster up his nose. By "everyone" we include the pilot and the copilot. Throughout the rest of the movie they wander about plenty times, both at the same time. The automatic pilot was knocked offline by the storm, and as Bob mentions in a later conversation, it was never fixed. So, who is driving the plane? Rhetorical question.