Continuity mistake: At the press conference, McArthur is going full "no comment" about pretty much anything. A grim Alex Cross is standing there. Next to him are the senator's wife and the senator. At the cut the senator disappears, leaving just the wife and the FBI agent. (01:11:10)
Other mistake: When Prot visits the doctor's house, he thanks the wife and the camera is zoomed into his sunglasses. The reflection of his glasses shows the doctor looking at him, but the doctor is standing behind him. (00:53:40)
Continuity mistake: During Buffalo Bob's first appearance, he's holding a rake with both hands. In the next shot, he's holding it with just one hand.
Continuity mistake: When Bobby is begging his mother to let him work for Ted Brautigan, she says yes and fully ties the apron around her waist. However in the next shot, she is shown just putting the apron around her waist and tying it again. (00:21:50)