Trivia: Ross Marquand, who voices Professor X, previously portrayed Red Skull in Avengers: Infinity War and Avengers: Endgame. Cedric Smith, who voiced Professor X in the original animated series, also voiced Red Skull in one of the series' final episodes.
Trivia: For reasons yet to be disclosed by either party, series creator Beau DeMayo was fired by Disney only days before its Disney+ premiere. Despite his firing, DeMayo regularly interacted with fans on X (formerly Twitter) regarding plot details following the release of each episode, as well as recommending what episodes from the original series fans should watch in preparation for the release of certain episodes of this series.
Trivia: Several actors from the original series are returning to voice different characters. Chris Potter, who voiced Gambit, will now be voicing Cable, while original Cable actor, Lawrence Bayne, will be voicing X-Cutioner. Catherine Disher, who voiced Jean Grey, will be voicing Valerie Cooper. Ron Rubin, who voiced Morph, will be voicing President Kelly. Alyson Court, who voiced Jubilee, will be voicing Abcissa, who is an older and digital replica of Jubilee.
Trivia: A.J. LoCascio is taking over the role of Gambit from Chris Potter. He said he initially didn't know he was going to be recording for a revival of the original animated series, rather he thought it was going to be for a video game. LoCascio grew up a huge fan of Gambit. He even took French classes in school because of it, and referred to himself in those classes as "Remy" (Gambit's real name).
Trivia: Jennifer Hale is taking over the role of Jean Grey from Catherine Disher. Hale previously voiced Jean Grey in Wolverine and the X-Men. She also previously voiced Felicia Hardy/Black Cat and Julia Carpenter/Spider Woman in the 90's Spider-Man and Iron Man animated series, respectively, which take place in the same continuity as this show.
Trivia: Ahead of its premiere, it was announced that Morph, who was created for the original animated series, would be non-binary. This led to backlash from some fans, claiming that the show was going "woke." Eric and Julia Lewald, who created the original series, pushed back against these fans, asking if they had learned nothing from the show and the comics that inspired it, as it was always an allegory for civil rights and highlighted people who were different from the norm and dealt with bigotry.
Trivia: Alyson Court, who voiced Jubilee in the original series, opted not to voice Jubilee again so that an Asian voice actress could take over the part, who was later revealed to be Holly Chou.