The White Asparagus Triangulation - S2-E9
Continuity mistake: When Sheldon is questioning Raj and Howard in the cafeteria, the bottle of water is on Raj's tray faces the camera with the barcoded side. But in one closeup it rotates to show the logo-branded side.
The Middle Earth Paradigm - S1-E6
Continuity mistake: When Leonard is talking to Sheldon in the kitchen about the party, Sheldon is pouring juice. In one shot he places the bottle cap on the bottle yet in the next shot his hand is down on the counter with the lid in it. (00:04:50)
The Vegas Renormalization - S2-E21
Continuity mistake: In the bathroom of the hotel in Las Vegas, we can see Rajesh taking a small white bottle and keeping it in his hand while saying "I love Las Vegas". In the next shot, the bottle has returned to its place instantly.
The Nerdvana Annihilation - S1-E14
Continuity mistake: In the scene where Leonard is packing up his collectables to sell, at 15:32 he is dusting what appears to be a Hasbro Marvel Legends Yellow jacket figure, which also has a yellow post-it on the back. At 15:42 he is still dusting a figure but he now holds a different (darker but not yellow) figure from the same series, with no post-it on the back, and the Yellow jacket figure is now on the table (house left of the box of collectables). At 15:56 The Yellow jacket figure has disappeared from the table, and it is not the figure in Leonard's hands either. (00:15:30)
Continuity mistake: When Sheldon is talking with Leonard in the kitchen at night, as he pours himself a mug of milk the mug moves between shots. (00:04:50)
Deliberate mistake: Whenever anyone walks across the front hallway, it takes them 6-7 seconds to walk from one stairway to the other. On the backside of the stairway, it only takes 1-2 seconds to walk across.
The White Asparagus Triangulation - S2-E9
Continuity mistake: When climbing the stairs at the start, Penny and Sheldon turn the corner and carry on the conversation. Camera cuts and now they turn the corner again and continue their conversation without breaking it.
The Clean Room Infiltration - S8-E11
Other mistake: When Howard, Leonard, and Raj are arguing in the clean room, Howard says that Leonard is jealous because Howard and Leonard used to be "best friends until Koothrapali came along." Yet, in the earlier seasons, we know that Howard and Raj already knew each other when Leonard met them for the first time and brought them back to the apartment to play video games. Meaning they couldn't have been best friends before Raj came along.
The Werewolf Transformation - S5-E18
Character mistake: In S5-15, Sheldon is asking his friends to take him to SuperCuts. But in this episode, he goes to Mr. D'Onofrio's barber shop where he says he's gone to since he moved to CA, and he said D'Onofrio had his "haircut records."
The Hamburger Postulate - S1-E5
Continuity mistake: Leonard and Leslie are rehearsing the violin and cello in the guys' living room, and when they leave the room to go to Leonard's room, Leonard's cello and stand are still in front of the comfy chair. When Sheldon gets home, the cello and stand are gone, and only Leslie's closed violin case is left on the sofa. And she picks it up and leaves with it. How did the violin get back in the case.
The Retraction Reaction - S11-E2
Deliberate mistake: Leonard is on NPR on a Friday, and the guys don't talk about it until the following Monday at work. They spend so much time together, they surely would've discussed it sooner.
The Retraction Reaction - S11-E2
Character mistake: When Leonard arrives at the Human Resources office, he tells the HR person that he's not used to being called into the Dean's office. He's not in the Dean's office, he's in HR.
The Convergence Convergence - S9-E24
Other mistake: Howard believes he's being followed by the government, when it's actually Leonard, Penny, and Beverly in their car. The shots from Howard's car show only Leonard's silhouette. The other two do not appear as silhouettes.
The Higgs Boson Observation - S6-E3
Factual error: Sheldon tells Alex that he's run a background check, including her medical records. There is no way he could obtain medical records without a HIPAA authorization signed by Alex herself. It's illegal.
The Countdown Reflection - S5-E24
Continuity mistake: Penny mentions that she knows lots of people who got married in Las Vegas. In episode 7/9, she discovers that her "fake" wedding to Zach in Vegas was real.
Continuity mistake: Sheldon puts the bag of takeout into the lobby trash can and as he does so, the whole bag turns sideways. At the end of the scene, he takes the bag out of the can and it's upright without him turning it.
Continuity mistake: When Leonard is consoling Penny on the couch, the blue Afghan she has with her constantly changes position, including jumping from the floor back to the couch.
Continuity mistake: Throughout the early episodes, shots of Sheldon's bathroom shows the door open and a rack of towels against the wall. Later episodes show that that area is actually where the sink and mirror are.
The Colonization Application - S8-E17
Character mistake: Leonard and Penny were using the body paint the second time, the entire canvas is covered, and they each are covered with paint. But not a bit got into their hair.
The Hamburger Postulate - S1-E5
Continuity mistake: When Sheldon is explaining to Leonard why a Cheesecake Factory Hamburger is superior to a Big Boy Hamburger the number of fries on Leonard's plate noticeably changes between shots.
Chosen answer: It does. The variable cleanliness of the cab and the habit of taxi drivers to engage customers in small talk would be too much for Sheldon to handle, and not an option for him.
Captain Defenestrator